McComb is a city in Pike County, Mississippi, United States. The city is approximately 80 miles south of Jackson. As of the 2010 census, the …McComb is a city in Pike County, Mississippi, United States. The city is approximately 80 miles south of Jackson. As of the 2010 census, the city had a total population of 12,790. It is the principal city of the McComb, Mississippi Micropolitan Statistical Area.