A mobile state of the kinesin–ADP head is discovered using multi- and single-molecule fluorescence polarization. The structure of the microtubule–kinesin complex has been determined by cryo-EM. The ...

Kinesin is an ATP-driven molecular motor protein that moves processively along microtubules. Despite considerable research, the detailed mechanism of kinesin motion remains elusive. We applied an ...

Researchers used a novel phosphate-activation reagent, 2-MeImIm-Cl, in an improved coupling reaction to increase the yield of ADP- or ATP-containing molecules. Unlike traditional reactions, the ...

Researchers at Gifu University’s Institute for Glyco-core Research have developed two synthetic approaches to produce a fragment of a molecule called poly(ADP-ribose). By developing two ways to ...

The cells of all living organisms are powered by the same chemical fuel: adenosine triphosphate (ATP). Now, researchers have found a way to generate ATP directly from electricity, which could ...

Phase I trial involving the pharmacodynamic (PD) study of circulating tumour cells, of CP-751,871 (C), a monoclonal antibody against the insulin-like growth factor 1 receptor (IGF-1R), with docetaxel ...