Structure of hnRNPDL-2 amyloid fibres obtained by cryoEM at 2.5 A resolution. The upper part shows the organisation of the protein with two nucleic acid binding domains in pink and a low-complexity ...

The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion. While healthy transthyretin moves hormones through blood and spinal fluid, misfolded ...

Following the discovery at the turn of the twentieth century of distinctive plaques and neurofibrillary tangles in the brains of several people with memory loss and other neurodegenerative symptoms, ...

The retraction came from Neurobiology of Aging, which removed a 2011 paper claiming to show that a version of a protein ...

An estimated 50 million people worldwide have dementia, with Alzheimer's disease—accounting for more than 70%—being the representative neurodegenerative brain disorder. A Korean research team has, for ...

Aη, or A-eta, made an initial splash when scientists reported that these fragments of amyloid precursor protein—products of a heretofore unknown cleavage—dampen neural activity. But how? The story ...

In a recent study published in the journal PLOS Biology, researchers used mouse models to demonstrate that neurons were not the only source of abnormal amyloid β proteins contributing to the pathology ...

Share on Pinterest New research looks into the role of amyloid-beta in developing Alzheimer’s. Westend61/Getty Images A main theory behind the cause of Alzheimer’s disease is the build-up of the ...

Alzheimer's disease (AD) is a neurodegenerative disease that causes progressive memory loss and a significant decline in mental functions. Past studies have shown that people with AD exhibit a buildup ...

Researchers have developed a potential new peptide-based drug delivery system by repurposing fibrils that contribute to Alzheimer’s disease pathogenesis. Researchers at the University of North ...