Local mRNA translation is a post-transcriptional gene regulatory mechanism that enables autonomous control of local proteomes in subcellular compartments. This mechanism operates in neuronal dendrites ...

Axonal damage causes neurological defects in multiple sclerosis. In vivo imaging in mouse models of multiple sclerosis now shows a reversible and sequential process of focal axonal degeneration (FAD) ...

Researchers at VIB and KU Leuven have identified a molecular process that allows motor neurons to maintain protein production, a process that fails in amyotrophic lateral sclerosis (ALS). The study, ...

As axonal mitochondria are lost, changes in the subunits of eIF2 are seen which hamper translation and autophagy and cause the accumulation of proteins in cells. Tokyo, Japan – Researchers from Tokyo ...

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Organoids developed from human stem cells modeled spinal cord injuries, providing a powerful in vitro tool to evaluate ...

A research team led by investigators at McMaster University has identified an axonal guidance signaling pathway that cancer cells use to infiltrate the brain. The combined results of preclinical in ...

A hallmark of Parkinson's disease is the buildup of Lewy bodies—misfolded clumps of the protein known as alpha-synuclein. Long before Lewy bodies form, alpha-synuclein can interfere with neurons' ...

Left: confocal microscopy of a stained brain tissue slice from a rat. Right: the corresponding dMRI slice of the rat’s brain, shown with a voxel-wise map of the MR-derived effective radii. (Courtesy: ...

The family of Jules Bianchi, the Formula One racing driver who was critically injured at Sunday’s Japanese Grand Prix, have revealed that he is suffering from a “diffuse axonal injury.” It is a ...

Injured axons instruct Schwann cells to build specialized actin spheres to break down and remove axon fragments, thereby starting the regeneration process. Damaged peripheral nerves can regenerate ...

Giant axonal neuropathy (GAN) is a rare, autosomal recessive neurodegenerative disorder, characterized by a spectrum of symptoms and a challenging prognosis. Now, a study published recently in the New ...