In a recent study posted to the bioRxiv* preprint server, researchers assessed the binding pocket of linoleic acid (LA), an essential free-fatty acid (FFA) in the receptor-binding domains (RBDs) of ...

A study from St. Jude Children's Research Hospital uncovered an alternative binding pocket within nuclear receptors, revealing a much-needed new therapy route for this important class of drug targets.

Normal cells have a complex system of checks and balances that regulate cell division. In cancer, the balance is tipped in favor of cell proliferation. This imbalance arises from increased levels or ...

Progressing lesions of 25 patients with GISTs refractory to ripretinib were sequenced for KIT resistance mutations. Resistant genotypes were validated and characterized using novel cell line models ...

Coronaviruses have been around for a long time and have caused several recent deadly outbreaks. The most recent is the ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by the severe ...

RNA biologists at the University of Rochester Medical Center (URMC) have discovered that RNA, the chemical cousin of DNA, can bind two metabolites (small molecules) at the same time in a single ...

Investigators at the University of Bristol and Biognos AB have identified a structural feature that distinguished the deadly coronavirus strains from harmless, common cold-causing variants. The ...

Imaging at near-atomic resolution of a key immune protein commonly known as STING has revealed a previously unrecognized binding site that appears to be pivotal for launching immune attacks, UT ...