An intercellular signaling mechanism between adipocytes and hepatocytes could unlock new insights into metabolic disease.

The study reveals how ER-stressed adipocytes remotely regulate UPR activation in hepatocytes through the secretion of ceramide ... signaling molecules capable of activating the UPR pathway ...

Our laboratory focuses on the role of sphingolipid signaling as a stress response. In this pathway, generation of the second messenger ceramide in response to diverse environmental and pharmacologic ...

Our laboratory focuses on the role of sphingolipid signaling as a stress response. In this pathway, generation of the second messenger ceramide in response to diverse environmental and pharmacologic ...

This work systematically elucidated how the ceramide-FPR2 signaling axis regulates adipocyte ... As a central molecule in the sphingomyelin metabolic pathway, ceramide is closely associated ...

By systematically mapping the molecular pathway of UPR signal transmission between adipose ... More information: Yazhen Huo et al, Ceramide mediates cell-to-cell ER stress transmission by ...

As a central molecule in the sphingomyelin metabolic pathway, ceramide is closely associated with metabolic disorders such as diabetes, obesity, and atherosclerosis. Current research has revealed its ...