Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event for DNA to be the molecule that codes all life. A new study from King ...

If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...

Brandt Eichman and Walter Chazin, professors of biochemistry, have worked together to provide a better understanding of how exactly DNA replication is initiated in eukaryotes. Using Vanderbilt's state ...

A major obstacle to studying DNA replication is that it involves asynchronous and highly delocalized events. A reversible replication barrier overcomes this limitation and allows replication fork ...

The alternative text for this image may have been generated using AI. Fig. 1: The formation of eccDNA fib-L is detected in different cells. The alternative text for this image may have been generated ...

Further investigation suggested that this behavior was due to replication stress, an impaired ability of cells to copy their DNA in preparation for cell division. Further experiments showed that ...

Researchers reveal how DNA gyrase resolves DNA entanglements. The findings not only provide novel insights into this fundamental biological mechanism but also have potential practical applications.

Stepping away from its billions-of-years-old role as a genetic "blueprint," DNA is now embarking on a new journey as an active "field agent" within cells. This research by a team led by Professor ...