DNA is the blueprint of life. Genes encode proteins and serve as the body's basic components. However, building a functioning organism also requires precise instructions about when, where, and how ...

When two homozygous plant lines with different characteristics are crossed, the resulting offspring are often more robust and productive than their parents. This phenomenon is called heterosis. It can ...

In a scientific feat that broadens our knowledge of genetic changes that shape brain development or lead to psychiatric disorders, a team of researchers combined high-throughput experiments and ...

In disease research, it's important to know gene expression and where in a tissue the expression is happening, but marrying the two sets of information can be challenging. "Single-cell technologies, ...

Scientists from Gladstone Institutes, UC San Francisco and Stanford University, in collaboration with Biohub, have unveiled a massive, high-resolution functional map of human immune cells that ...

Scientists have revealed the DNA sequence code of the “initiator,” a crucial sequence that kick-starts gene activation. A machine learning analysis of a half million experimental data points yielded ...

e2MPRA allows researchers to introduce any nucleotide substitutions across regulatory sequences and assess their variant effects on gene expression, DNA accessibility, and epigenetic modifications at ...

The study is part of the PsychENCODE Consortium, which brings together multidisciplinary teams to generate large-scale gene expression and regulatory data from human brains across several major ...