Nature

Integration of multiple machine learning approaches develops a gene mutation-based classifier for accurate immunotherapy outcomes

In recent years, the advent of immune checkpoint blockade (ICB) targeting programmed death-1 (PD-1), programmed death ligand-1 (PD-L1), and cytotoxic T lymphocyte-associated protein-4 (CTLA-4) has ...
Nature

In vitro comparison of the susceptibilities of the same drug resistance mutations to reverse-transcriptase inhibitors of subtype B and CRF01_AE HIV-1 strains

As the recommended drugs for first-line regimens in HIV-1 infections, reverse-transcriptase inhibitors (RTIs) are widely used around the world. To escape from the selective pressure imposed by RTIs, ...
Medical Xpress

New mutation hotspot discovered in human genome

Researchers have discovered new regions of the human genome particularly vulnerable to mutations. These altered stretches of DNA can be passed down to future generations and are important for how we ...