This module explores the synthesis of amines with a focus on the reductive amination reaction. Numerous examples from the discovery and commercial manufacturing of pharmaceuticals are included. After ...

Tertiary amines, made of a nitrogen bound to three carbons, occur frequently in drug structures but are complicated to make. Synthesis often requires multiple steps under different reaction conditions ...

Amines are ubiquitous in the pharmaceutical and chemical industries, and a nickel-based catalyst has now opened up a promising route to make these molecules from widely-available nitrile compounds ...