A defect in mitochondrial tRNA modification impairs the proper formation of mitochondrial OXPHOS complexes, which results in iron transmigration from mitochondria to cytosol. Excess cytosolic iron ...

Heme, the iron-holding molecule that gives blood its red color, is essential for life. Yet, ironically, it can be quite toxic if not properly handled. In fact, numerous diseases – from various cancers ...

LSD1 promotes glycolysis and heme synthesis in erythroblastic leukemia (EL) cells (IMAGE) ...

In a recent study published in Nature Metabolism, researchers combine traditional clinical indicators with cutting-edge metabolomics data to investigate the processes underlying dietary heme iron ...

Higher intake of heme iron, the type found in red meat and other animal products -- as opposed to non-heme iron, found mostly in plant-based foods -- was associated with a higher risk of developing ...