The attachment of sister kinetochores to microtubules from opposite spindle poles is necessary for accurate chromosome segregation during cell division. Unattached kinetochores activate the cell-cycle ...

(Phys.org) -- With the first-ever three-dimensional image of an isolated kinetochore – the bulky molecular machine that connects a chromosome to the long, thin microtubules that tug it to one end of a ...

The kinetochore is a large proteinaceous structure that mediates interactions between chromosomal DNA and spindle-microtubule polymers. More than 80 kinetochore proteins have been identified using ...

In human cells, lengthy strands of DNA have to be carefully organized and compacted so they'll fit into the nucleus; our genome is arranged into chromosomes that have to be duplicated each time a cell ...

A multilayered protein structure called the kinetochore executes the chromosome delivery program. In a highly interdisciplinary collaborative tour-de-force, the groups of Andrea Musacchio and Stefan ...

The protein complex responsible for the distribution of chromosomes during cell division is assembled in the transition regions between heterochromatin and euchromatin. The centromere is a specialized ...

Thousands of our cells successfully divide every day. They replicate their DNA and then separate so that each of the new cells has the same complement of chromosomes. If the process goes wrong and ...

As a cell divides, its DNA -the genetic material- is duplicated and condensed into structures called chromosomes, which are carefully organized and distributed so that each daughter cell acquires a ...

Scientists report that two proteins once thought to have only supporting roles, are the true "stars" of the kinetochore assembly process in human cells. The kinetochore is vital to proper DNA ...

Cell division is essential for the correct transmission of genetic information. Each chromosome within a plant contains a centromere, a region that plays a central role in controlling chromosome ...

Cell division builds our bodies, supplying all cells in our tissues and organs, from the skin to the intestine, from the blood to the brain. It not only allows these organs to grow, but also to ...

This release is available in German. The centromere is a specialized region of the chromosome, on which a protein complex known as the kinetochore is assembled. During cell division, the kinetochore ...