Florio’s pick: Lions, 27, Vikings 20. Simms’s pick: Lions, 27, Vikings 17. The Broncos will run up the score in this one, if they can. Florio’s pick: Broncos 30, Chiefs 10. Simms’s pick: Broncos 28, Chiefs 10.

The Cardinals could be headed toward a coaching change after Jonathan Gannon's third straight losing season. The Bengals could be in a similar spot with coach Zac Taylor, and quarterback Joe Burrow hasn't seemed happy in Cincinnati.

Each pick has a confidence level of 1-10, with 10 being the most confident. For more information on the pick methodology, check out the Week 1 edition of this series. Keep in mind that since the idea here is to make high-percentage plays,