Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. Researchers have taken a ...

Opioid medications offer people relief from debilitating pain, but these drugs come with dangers: the risk for addiction, miserable withdrawal symptoms and the potential for fatal overdose.

Researchers in Japan have developed a new type of painkiller that may one day offer strong pain relief without the dangerous risks linked to opioid drugs such as morphine and fentanyl. The new ...

Naloxone, also known by the brand name Narcan, is one of the most important drugs in the United States’ fight against the opioid crisis. It reverses an opioid overdose nearly instantly, restarting ...

Opioid antagonists are medications people can take to treat opioid use disorder. They help by reducing withdrawal symptoms, addressing cravings, and managing overdoses. Doctors prescribe opioid ...

GLP-1 receptor agonists, already used for Type 2 diabetes and obesity, show promise in reducing alcohol and drug-seeking ...