E3 ligases transfer ubiquitin to target proteins for degradation ... generate soluble recombinant E3 ligases Cereblon, VHL, and Parkin. Full-Length Cereblon Cereblon Δ1-42:Cereblon with residues ...

PARK2/PARKIN PARK2 is characterized by genetic defects in the parkin protein, an E3 ubiquitin ligase that targets misfolded proteins to the UPS. Defective parkin activity results in the aberrant ...

In this study, we will establish the role of RING genes in fungal susceptibility using a RING gene knockout collection and Botrytis cinerea as model pathogen, through the high-throughput screening ...

These innovative compounds leverage the ubiquitin-proteasome system (UPS) to degrade challenging targets, providing new avenues for intervention beyond traditional small molecules. However, the power ...

Stuart Parkin is Director at the Max Planck Institute of Microstructure Physics, Halle, Germany, and an Alexander von Humboldt Professor at the Martin Luther University Halle-Wittenberg. His research ...

The Centre for Protein Degradation has two main objectives: PROteolysis Targeting Chimeras (PROTACs) are heterobifunctional molecules rationally designed to bring the desired target protein in close ...

Your daily dose of what's up in emerging technology Founded at the Massachusetts Institute of Technology in 1899, MIT Technology Review is a world-renowned, independent media company whose insight ...

In “The Forbidden Garden,” Simon Parkin examines the mad, heroic decision during the siege of Leningrad to guard biodiversity at the cost of human life. By Deborah Blum Deborah Blum ...

Meteorologist Jason Parkin first joined the KCCI 8 News team in 1998 and later returned in May 2016. Jason previously worked at WHO-TV and KCWI until it was sold to WOI. He has also worked at ...

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