Alternative polyadenylation is a vital gene function regulatory mechanism, occurring in more than 60% of human genes. The process is required for the synthesis of diverse mRNAs and proteins from a ...
Two potential mechanisms for suppressing transcription elongation in the upstream antisense region of gene transcription start sites (TSSs) include inefficient release of paused RNAPII and/or early ...
Cells regulate RNA and protein abundance through a multi-layered process. Excitingly, peeling back one layer has revealed additional layers below, highlighting the complex nature of this process. For ...
A team led by Dr. Eddie Imada, assistant professor of research in pathology and laboratory medicine, has been awarded a three-year, $1.5 million United States Department of Defense grant for research ...
A team led by Dr. Eddie Imada, assistant professor of research in pathology and laboratory medicine, has been awarded a three-year, $1.5 million United States Department of Defense grant for research ...
Meet PolyA-miner, a new computational tool that enables scientists to evaluate the contribution of alternative polyadenylation to gene regulation in health and disease. Researchers with an interest in ...
In a comprehensive review of recent genetic studies, researchers have identified a hidden layer of complexity in how our genes function, shedding new light on the biological underpinnings of major ...
In TDP-43 proteinopathies, such as frontotemporal dementia, amyotrophic lateral sclerosis, and limbic predominant age-related TDP-43 encephalopathy, the notorious RNA binding protein abandons its post ...
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