Other experiments to assess the acute toxicity of silymarin were performed in beagle dogs, rabbits, Wistar rats and NMRI mice after an intravenous bolus dose. Silymarin was used as the ...

and used for the simultaneous detection of berberine (BBR), astragaloside IV (AST), and the main metabolites to demonstrate the comparative pharmacokinetics of BBR and AST in normal and T2DM rats.

Juvenile and adult male rats were implanted with intravenous catheters and tested for self-administration 4 days later at postnatal day 27 or 90, respectively. Animals were tested, without prior ...