Over 30 years ago, receptors for the Fc region of IgG (FcγR) were implicated in the pathogenesis of systemic lupus erythematosus (SLE). Since those pioneering studies, our knowledge of the structure ...

P2X7 is a purinergic receptor and adenosine triphosphate (ATP)-gated cation channel. 11 P2X7 is activated by nicotinamide adenine dinucleotide (NAD)-induced adenosine diphosphate (ADP) ribosylation, ...

Autoimmune drug development increasingly recognizes that the Fc-FcR axis is more than an effector mechanism; it is a controllable immunological node that bridges humoral and cellular responses. This ...

In a recent study posted to the bioRxiv* preprint server, researchers elucidated pan-sarbecovirus immune protection mechanisms by utilizing a Venezuelan equine encephalitis virus-vectored vaccine ...

In a recent study, Alexander von Humboldt Professor Jijie Chai at the University of Cologne and his team together with MPIPZ researchers have succeeded for the first time in reconstructing the ...

Scientists have revealed that direct physical associations between plant immune proteins and fungal molecules are widespread during attempted infection. The authors' findings run counter to current ...

G protein–coupled receptors (GPCRs) play crucial roles in the regulation of a wide variety of physiological processes and represent one-third of targets with clinically prescribed drugs. Yet, it ...

In the animal kingdom, predators use a full range of strategies, such as camouflage, speed and optical illusions, to catch their prey. Meanwhile, prey species resort to the same tactics to escape from ...

A GIF showing a protein mimicking IL-2 binding to IL-2 receptors, then changing shape in response to an effector molecule, which forces it off of one of the receptors. A protein mimicking IL-2 called ...

Zanidatamab, an anti-HER2 bispecific antibody, plus chemotherapy with/without tislelizumab as first-line treatment for patients with advanced HER2-positive breast cancer or gastric/gastroesophageal ...