A team of Chinese researchers led by Prof. WANG Likun from the Institute of Biophysics of the Chinese Academy of Sciences has provided new insights into metabolic disease mechanisms and potential ...

The study reveals how ER-stressed adipocytes remotely regulate UPR activation in hepatocytes through the secretion of ceramide (Cer ... adipocytes secrete bioactive signaling molecules capable of ...

Our laboratory focuses on the role of sphingolipid signaling as a stress response. In this pathway, generation of the second messenger ceramide in response to diverse environmental and pharmacologic ...

This work systematically elucidated how the ceramide-FPR2 signaling axis regulates adipocyte ... As a central molecule in the sphingomyelin metabolic pathway, ceramide is closely associated ...

Our laboratory focuses on the role of sphingolipid signaling as a stress response. In this pathway, generation of the second messenger ceramide in response to diverse environmental and pharmacologic ...

By systematically mapping the molecular pathway of UPR signal transmission between adipose ... More information: Yazhen Huo et al, Ceramide mediates cell-to-cell ER stress transmission by ...

As a central molecule in the sphingomyelin metabolic pathway, ceramide is closely associated with metabolic disorders such as diabetes, obesity, and atherosclerosis. Current research has revealed its ...