In these LNPs, ionizable lipids were more tightly associated with siRNA, forming a stacked bilayer structure that enhanced gene silencing. In contrast, post-mixed LNPs displayed a more ...

RNA therapies show promise for treating diseases like cancer and genetic disorders, but their effectiveness depends on proper delivery. A recent study found that the method of mixing siRNA with lipid ...

Penn Engineers have discovered a novel means of directing lipid nanoparticles (LNPs), the revolutionary molecules that delivered the COVID-19 vaccines, to target specific tissues, presaging a new era ...

Penn Engineers have discovered a novel means of directing lipid nanoparticles (LNPs), the revolutionary molecules that delivered the COVID-19 vaccines, to target specific tissues, presaging a new ...

This review describes the impact of contact lens wear on the tear film lipid layer and how changes in the lipid layer might modulate contact lens-related discomfort. Relevant clinical, functional ...

Rolando and Refojo 55 Temperature and humidity sensors interconnected with a constant humidity conditioning unit 4.1 (0.4) 30 Tsubota and Yamada 56 A temperature and humidity sensor placed inside ...

suggesting that such genes are expressed at lower levels in LLMs than in macrophages that are not lipid laden. These changes in chromatin accessibility were associated with enhanced ...

MEMPHIS, TENN. -- A former Memphis police officer who has pleaded guilty to violating Tyre Nichols’s civil rights testified in tears Tuesday, saying he left Nichols’s young son fatherless ...