E3 ligases transfer ubiquitin to target proteins for degradation ... generate soluble recombinant E3 ligases Cereblon, VHL, and Parkin. Full-Length Cereblon Cereblon Δ1-42:Cereblon with residues ...
PARK2/PARKIN PARK2 is characterized by genetic defects in the parkin protein, an E3 ubiquitin ligase that targets misfolded proteins to the UPS. Defective parkin activity results in the aberrant ...
An E3 ligase TRAF7 regulates time-of-the-day-dependent expression of DBP proteins via the ubiquitin-proteasome system, providing insight into the posttranslational regulation of clock proteins in ...
These innovative compounds leverage the ubiquitin-proteasome system (UPS) to degrade challenging targets, providing new avenues for intervention beyond traditional small molecules. However, the power ...
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