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Camilla Luddington and Jessica Capshaw detailed their reaction to Sophia Bush joining Grey’s Anatomy season 21—and her chemistry with Kim Raver—in an exclusive E! News interview.

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The fall finale of Grey's Anatomy Season 21 ended with not one but two cliffhangers. The episode also bid farewell to one of its own, with a difficult case involving Amelia and Winston.

Vinessa Antoine, best remembered for her role in the medical drama General Hospital, is back and will be seen in another popular medical drama Grey’s Anatomy.