BEERSHEBA, Israel (AP) — Israel’s defense minister threatened Iran’s supreme leader on Thursday after the latest missile barrage from Iran damaged the main hospital in southern Israel and hit several other residential buildings near Tel Aviv. Israel meanwhile struck a heavy water reactor that is part of Iran’s nuclear program.

The Arrow system intercepts long-range missiles at higher altitudes; the David’s Sling system intercepts them at lower altitudes; while the Iron Dome takes out shorter-range rockets, usually fired from Gaza, or the fragments of missiles already intercepted by other defense systems.