Introduction Chronic rhinosinusitis with nasal polyposis (CRSwNP) affects a significant proportion of people with severe asthma (SA). Despite the effectiveness of anti-IL5/5R therapies in the ...

Background and Aims The SARS-CoV-2 (COVID-19) pandemic caused significant global mortality and morbidity. Recent studies report residual lung abnormalities (RLA) and evidence of lung fibrosis in some ...

Environmental factors, here taken to include pollutants, lifestyle factors and behaviours, can play an important role in serious, chronic pathologies with large societal and economic costs, including ...

Introduction With improving cancer outcomes, indeterminate pulmonary lesions following radically-treated cancer are increasingly common, posing a diagnostic challenge of underlying aetiology. Existing ...

8 Biometrics, Late-stage Development, Respiratory and Immunology, BioPharmaceuticals RandD, AstraZeneca, Cambridge, UK 9 Late-stage Development, Respiratory and ...

Background Asthma remains the most common chronic disease in children and the UK has some of the poorest asthma outcomes in Europe. The socio demographic inequalities contribute to severe asthma ...

Background Bronchoalveolar lavage (BAL) is essential in determining the efficacy of novel therapies in alpha-1 antitrypsin deficiency (AATD). These require initial proof-of-concept demonstration that ...

Introduction Tezepelumab, a human monoclonal antibody targeting TSLP, inhibits T2 inflammation leading to a fall in both the blood eosinophil count (Eos) and fractional exhaled nitric oxide (FeNO) ...

Background The evidence base on montelukast-associated adverse outcomes is inconclusive in children and young persons (CYP) with asthma. We aimed to investigate 1-year incidence of neuropsychiatric ...

2 Institute of Respiratory Medicine, University of Sydney, NSW, Australia 3 South Western Sydney Clinical School, University of New South Wales, NSW, Australia Background: Sahaja Yoga is a traditional ...

Background Patient perception of asthma treatment is rarely captured, and no specific tools exist to measure it. We developed an inhouse severe asthma patient feedback questionnaire (SAPFQ) using ...

Introduction and Objectives Gene therapy for cystic fibrosis is approaching clinical trials. Using a lentiviral vector pseudotyped with Sendai virus fusion and hemagglutinin-neuraminidase proteins, ...