A 58-year-old man presents for a routine annual physical. During the exam, he mentions an intermittent sensation like a “rush of anxiety” that begins in the abdomen and chest and radiates to the head.

Pegcetacoplan inhibits C3 activation by binding to C3 and its activation fragment C3b, thereby reducing C3 glomerular fragment deposition in patients with C3G and primary IC-MPGN.

These findings may partially reflect both structural barriers that delay timely diagnosis and the impact of local equity-driven initiatives that broaden colorectal cancer screening access.