Focal cortical dysplasia (FCD) type 2 is a congenital malformation of the cerebral cortex that is often associated with difficult-to-treat epilepsy. In the affected areas, nerve cells and their layer ...

Osteoarthritis (OA) is one of the most prevalent conditions affecting tens of millions of U.S. adults, traditionally ...

Bacteria naturally present in the human intestine (known as the gut microbiota) can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking ...

For the first time, the smallest control system of vision in mammals has been mapped—a discovery that opens entirely new insights into how our vision works and how it can be affected by disease.

Scientists develop lab-grown model of the human sensory pathway to investigate how pain signals are transmitted to the brain.

This also showed that the regulation of ceramide metabolism causes vascular dysfunction and inflammation in obesity." The paper suggests that targeting this metabolic pathway could have multiple ...

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are essential for a wide range of cellular functions-as enzymes, transporters, ...

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are ...

The study reveals how ER-stressed adipocytes remotely regulate UPR activation in hepatocytes through the secretion of ceramide (Cer ... adipocytes secrete bioactive signaling molecules capable of ...

In addition, metabolites (IAld and quinolinic acid) from skin microbiota relieve skin inflammation by activating AHR signaling in keratinocytes. This pathway ... by producing ceramides and ...