Researchers have detailed the structure of the Ebola virus nucleocapsid using cryo-electron tomography. This discovery could guide the development of universal antiviral therapies targeting multiple ...

Ollmann Saphire hypothesizes that these cloaking molecules are shed in layers when the virus approaches a cell. The structure also revealed that within the protein - a trimer made up of GP1 and GP2 ...

Inspecting the enemy The Ebola virus relies on its nucleocapsid structure to protect and replicate its own genetic material inside host cells—and suppress host cellular immunity.

Discovery of nucleocapsid structure paves the way for antivirals against Ebola virus and other filoviruses.

The protein – the C-terminal domain of the Zaire Ebola virus nucleoprotein – is the most abundant viral protein in infected cells, and also the most abundant in the nucleocapsid, the structure ...

Inspecting the enemy Ebola virus relies on its nucleocapsid structure to protect and replicate its own genetic material inside host cells -- and suppress host cellular immunity.

Scientists have determined the structure of a critical protein from the ebola virus, which, though rare, is one of the deadliest viruses on the planet killing between 50 and 90 percent of those ...

Ebola virus takes the alternative route: its genome encodes a protein that can copy RNA into RNA. This gene (creatively called the polymerase, or L) is the largest one carried by the virus.

Application of cryo-electron tomography and subtomogram averaging to determine the structure of the Ebola virus nucleocapsid within intact viruses and recombinant nucleocapsid-like assemblies.

When the NPC1 gene is mutated, the Ebola virus cannot enter the cell. The team identified NPC1 from cells of patients with a rare genetic disorder called Niemann-Pick, type C1.