With its 35-10 loss at Buffalo on Sunday night, the 49ers have now dropped three straight to sink to 5-7 on the season. The blowout loss also marked the first time since 2015 and just the fourth time in franchise history that San Francisco has lost back-to-back games by 25 points or more.

Patrick Everson breaks down the football weekend that was, including how the 49ers' struggles impacted the books, and some mixed reactions after UM stunned Ohio State.

San Francisco 49ers head coach Kyle Shanahan revealed after Sunday night's loss to the Buffalo Bills that running back Christian McCaffrey suffered a

The San Francisco 49ers endured another disheartening loss Sunday night, falling to the Buffalo Bills and dropping to 5-7 on the season. With their playoff hopes dwindling, questions are mounting about the direction of the team and the job security of head coach Kyle Shanahan and general manager John Lynch.

A picturesque setting of snow was the perfect backdrop for a Buffalo Bills team that has now won its fifth straight AFC East title.

Buffalo Bills running back James Cook looked phenomenal in his team's Week 13 win over the San Francisco 49ers, and his brother wants him to be compensated.

A pair of Super Bowl hopefuls from each conference meet up on Sunday, Dec. 1 to close out the NFL schedule for the day with the Buffalo Bills hosting the San Francisco 49ers at Highmark Stadium in Orchard Park, NY.

Buffalo Bills quarterback Josh Allen had fun in the snow as his team produced an offensive avalanche to blow away the San Francisco 49ers 35-10 in the NFL on Sunday. Allen followed up that score with a 7-yard pass to Mack Hollins,

SportsLine's model has simulated San Francisco vs. Buffalo on Sunday Night Football 10,000 times and revealed its SNF picks and NFL predictions