Mitochondria play a crucial role in acquiring pluripotency and determining cell fate. The mitochondrial unfolded protein ...

The beta-oxidation pathway of fatty acid and long chain acyl-CoA yields acetyl-CoA that enters the mitochondrial ... results in a decreased ATP/ADP ratio and an increased lactate/pyruvate ratio [20].

The researchers identified the structure of this machine, the mitochondrial pyruvate carrier (MPC), and 50 years since its discovery, have shown how it operates like the lock on a canal to transport ...

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the ...

Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971, but it has taken until now for scientists to visualise its structure at the atomic scale ...

This useful study reports a method to detect and analyze a novel post-translational modification, lysine acetoacetylation (Kacac), finding it regulates protein metabolism pathways. The study unveils ...

Researchers from Tohoku University challenged the mouse brain with a metabolic load induced by epileptic seizures, and observed fluctuations in blood volume, astrocytic pyruvate, and neuronal ATP.

Lately, Acetyl L-Carnitine, a known supplement, has attracted increasing attention. This supplement is a byproduct of L-Carnitine, an amino acid naturally present in the human body. Acetyl L ...