The 49ers — who were already without Trent Williams, Nick Bosa and Deommodore Lenoir — saw Christian McCaffrey leave their ...

The 49ers running back, the reigning NFL offensive player of the year, is facing a six-week recovery for a knee injury.

Former NFL wideout Ed McCaffrey said it was a tough night after his son, 49ers running back Christian McCaffrey suffered a ...

The 49ers just lost their second game in a row by at least 25 points for the first time since Jim Tomsula was the head coach.

Rather than viewing this team as one of the class organizations of the NFC, we now need to ponder whether injuries, age, and ...

The San Francisco 49ers endured another disheartening loss Sunday night, falling to the Buffalo Bills and dropping to 5-7 on ...

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

Christian McCaffrey’s injury threatens to sideline the 49ers’ star running back for the rest of the season. The team’s ...

Achilles tendinitis robbed San Francisco 49ers star Christian McCaffrey of the first eight games of the 2024 NFL season. A ...

The 49ers were among the preseason favorites to win the Super Bowl, but now they look like long shots to make the playoffs.

The weather outside was frightful at Highmark Stadium in Orchard Park, New York on Sunday night, but the way the San ...

The San Francisco 49ers' losses to the Green Bay Packers and Buffalo Bills mark the worst two-game stretch by a defending ...