Most starters were on the sideline late in Week 14's lopsided win, while only one D-lineman played over 30 snaps.

PM ET game airing live on Amazon Prime Video, bookmakers have posted player props for Isaac Guerendo. NFC West rivals play in ...

Linebacker Dre Greenlaw is cleared to suit up again for the 49ers tonight, 10 months after tearing his left Achilles in the ...

Getting hurt the Sunday before a Thursday night game gave San Francisco 49ers fans plenty of reason to be skeptical about ...

The San Francisco 49ers running back spot has been a position of focus for fantasy football players throughout the season, ...

The San Francisco 49ers have been decimated by injuries all year, specifically at the running back position. Christian ...

The San Francisco 49ers’ Week 15 injury report inspired a little bit of optimism on the health front as they enter a virtual ...

The 49ers won’t be down to their 4th-string running back tonight against the Rams as Isaac Guerendo is expected to play ...

The Los Angeles Rams will take on the San Francisco 49ers in Week 15 of the NFL season on Thursday. This prediction is based ...

Isaac Guerendo was initially uncertain for Thursday night, but the rookie looks like he might give it a go. Here's the latest ...

San Francisco 49ers running back Isaac Guerendo has a foot sprain, per head coach Kyle Shanahan. 49ers HC Kyle Shanahan said ...

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after ...