Getting hurt the Sunday before a Thursday night game gave San Francisco 49ers fans plenty of reason to be skeptical about ...

Most starters were on the sideline late in Week 14's lopsided win, while only one D-lineman played over 30 snaps.

The San Francisco 49ers have been decimated by injuries all year, specifically at the running back position. Christian ...

PM ET game airing live on Amazon Prime Video, bookmakers have posted player props for Isaac Guerendo. NFC West rivals play in ...

Isaac Guerendo was initially uncertain for Thursday night, but the rookie looks like he might give it a go. Here's the latest ...

The San Francisco 49ers running back spot has been a position of focus for fantasy football players throughout the season, ...

The 49ers won’t be down to their 4th-string running back tonight against the Rams as Isaac Guerendo is expected to play ...

If the San Francisco 49ers want to defend their NFC West title, they must defeat the Los Angeles Rams in Week 15. However, ...

According to ESPN's Adam Schefter, San Francisco 49ers rookie running back Isaac Guerendo is expected to suit up for Thursday ...

San Francisco 49ers running back Isaac Guerendo has a foot sprain, per head coach Kyle Shanahan. 49ers HC Kyle Shanahan said ...

The San Francisco 49ers running back is questionable with a sprained foot, but per ESPN’s Adam Schefter: he “plans to play” ...

“49ers rookie RB Isaac Guerendo plans to play Thursday night vs. the Rams despite his sprained foot that has left him being ...