The 49ers (5-7) are alone in last place in the NFC West for the first time since the 2020 season ended. On the heels of this defeat and last Sunday’s 38-10 rout in Green Bay, the 49ers return to Levi’s Stadium to host NFC North doormat Chicago (4-8) next Sunday at 1:25 p.m. in the Bears’ first game under interim coach Thomas Brown.

The San Francisco 49ers are reeling. They've lost two straight games to fall to 5-6 and under .500 for the fourth time this season. They continue to battle the injury bug, with quarterback Brock Purdy missing last week's loss to the Green Bay Packers.

The Buffalo Bills easily got past the San Francisco 49ers 35-10 on a snowy Sunday Night Football matchup. Here are winners and losers.