Discuss the clinical implications of an elevated AST/ALT ratio ... | Filo
Discuss the clinical implications of an elevated AST/ALT ratio ... | Filo
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1️⃣ AST (Aspartate Aminotransferase) Found in: Liver, heart, muscle, kidney, RBCs Located in both mitochondria and cytosol AST:ALT ratio > 2 → suggests alcoholic hepatitis Can rise in muscle injury (often with high CK) 2️⃣ ALT (Alanine Aminotransferase) More liver-specific than AST Mainly cytosolic ALT > AST → suggests viral hepatitis / hepatocellular injury 3️⃣ Alkaline Phosphatase (ALP) Found in: Bile ducts, bone, placenta Elevated in: Cholestasis (bile obstruction) Bone disease or growth If A
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